"A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptualization of underlying neural circuitry and a road map for future research".27 28 Various lines of evidence from post-mortem studies and the putative mechanisms of anti-manic agents point to abnormalities in GSK-3, 29 dopamine, Protein kinase C and Inositol monophosphatase.Archived from the original on Retrieved M-IV AJ Giannini.

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37 Punishment hyposensitivity, as reflected in a number of neuroimaging studies as reduced lateral orbitofrontal response to punishment, has been proposed as a mechanism of reward hypersensitivty in mania.Despite the unfortunate association implied by the name, however, no connection exists between mania or bipolar disorder and these disorders.

Giannini AJ, Houser WL, Loiselle RH, Giannini MC, Price WA (1984).Neuropsychiatry, Neuropsychology Behavioral Neurology.